Apart from saffron, it’s important that you tell them about any other supplements you’re taking, even if they’re natural. That way, they can check on any potential side effects or interactions with medications.

You may not be aware but supplements are not regulated by the FDA in the same way that food and drugs are.  The FDA does not review these for safety or efficacy before they hit the market. 

• Side effects. Using saffron supplements in the short-term seems safe for most people. They may cause side effects like anxiety, appetite changes, upset stomach, sleepiness, and headache.
• Using saffron in high doses or for long periods of time may be risky. Some people are also allergic to saffron.
• Risks. Saffron may trigger mood swings in people with bipolar disorder.
• Risks. Women who are pregnant or breastfeeding should not use saffron.
• Interactions. When used as a supplement, saffron may cause problems for people on blood pressure medicine or blood thinners. Check with your doctor before using it if you are taking medication.
• Likewise, there is also a slight chance of being allergic to saffron, especially if you already have other allergies to plants like rye-grass and foods such as olives.